Intravenous Push Drug Administration

An IV “push”, IVP or “bolus” is a rapid injection of a small volume of medication into patient’s vein via a previously inserted IV catheter. This method is used when a rapid response to a medication is required for example rapid control of heart rate, blood pressure, cardiac output or other critical conditions. While using the IVP the medications should not be pushed rapidly, they are administered in a short time frame (less than 5 minutes) but slowly enough as to not to cause a too rapid effect. After administering a drug with IVP an appropriate volume of IV flush (saline injection) is injected to ensure that the entire drug dose has been administered.

Solved Problem: Lorazepam is used for preoperative sedation at a dose 0.044 mg/kg IV for 1 dose; 15-20 minutes before surgery. How many ml of 2mg/ml solution should be administered to a patient weighing 200-lb?

Approach: Convert lb to kg,

$$ {200 \over 2.2 } = { 90.9 \ kg } $$

Calculate the dose based on weight,

$$ Dose \ for \ the \ patient = {90.9 \ kg \times 0.044 } {mg \over kg} = {4 \ mg} $$

Set up a ratio and proportion to calculate the ml of drug to be administered,

$$ {2 \ mg \over 1 \ ml} = {4 \ mg \over x \ ml} $$

Answer: 2 ml