Drug Dosage on Chemotherapy
Chemotherapy is the treatment of disease by the use of chemical substances, especially the treatment of cancer by cytotoxic and other drugs. Chemotherapeutic drugs are often administered orally, intravenously or by continuous intravenous infusion. Often times, 2, 3 or4 drugs are combined as a part of combination therapy to target the cancerous cells in different ways. A pharmacist should be able to calculate individualized dosing regimen using BSA and dose of each medication prescribed.
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Solved Problem: Regimen: AB Approach: Determine the BSA from nomogram, calculate the quantity of each drug.
$$ Drug \ A: { 30 { mg \over m^2 } \times 1.85 \ m^2 \times 4 \ days } = 222 \ mg $$ $$ Drug \ B: {125 { mg \over m^2 } \times 1.85 \ m^2 \times 1 \ day } = 231.25 mg$$ Answer: 222 mg, 231.25 mg |